Erratum: Recurrent ZFX mutations in human sporadic parathyroid adenomas
نویسندگان
چکیده
منابع مشابه
Recurrent ZFX mutations in human sporadic parathyroid adenomas
[This corrects the article on p. 360 in vol. 1, PMID: 25594030.].
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Context The molecular pathogenesis of sporadic parathyroid adenomas is incompletely understood, with alterations in cyclin D1/PRAD1 and MEN1 most firmly established as genetic drivers. The gene encoding the X-linked zinc finger protein (ZFX) has recently been implicated in the pathogenesis of a subset of parathyroid adenomas after recurrent, hotspot-focused somatic mutations were identified. ZF...
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P arathyromatosis is a multiple hyperfunctioning parathyroid tissue in the neck (1). In rare conditions it can cause hyperparathyroidism (1). It becomes hyperfunctioning after subtotal or total parathyroidectomy due to primary or secondary hyperparathyroidism (pHPT and sHPT). Palmer et al reported the first case of parathyromatosis (2), and were followed by the report of other 32 cases (1, 3-5)...
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BACKGROUND The potential pathogenetic significance of mitochondrial DNA (mtDNA) mutations in tumorigenesis is controversial. We hypothesized that benign tumorigenesis of a slowly replicating tissue like the human parathyroid might constitute an especially fertile ground on which a selective advantage conferred by mtDNA mutation could be manifested and might contribute to the oxyphilic phenotype...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2014
ISSN: 2331-4737
DOI: 10.18632/oncoscience.116